Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 25;13:872684. doi: 10.3389/fneur.2022.872684

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Rao, Xu, Sun, Li and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

MRI and CT findings and anti-aquaporin-4 antibody (AQP4-IgG) array of the presented case. (A) Whole-exome sequencing revealed a mutation in JAK2-V617F. (B) CT venography of the second hospitalization showed no filling defects of the cerebral venous sinus. (C–H) Spinal MRI demonstrated T2-weighted imaging abnormalities in the medulla as well as extensive spinal cord involvement extending from C1 to the conus. Spinal MRI with contrast showed mild enhancement in the cervical and thoracic spinal cord. (I,J) Follow-up MRI showed prominent regression of the hyperintense lesion, which included the medulla and spinal cord. (K) The serum titer of AQP4-IgG using a cell-based assay was 1:1,000 at the time of neuromyelitis optica spectrum disorder diagnosis. (L) The patient was negative for AQP4-IgG at the 1-year follow-up.