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. 2022 Apr 25;9:889963. doi: 10.3389/fcvm.2022.889963

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Copyright © 2022 Varasteh, Braeuer, Mohanta, Steinsiek, Habenicht, Omidvari, Topping, Rischpler, Weber, Sager, Raes, Hernot and Schwaiger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative ⁶⁸Ga-NOTA-anti-MMR Nb PET/CT (A) coronal and (B) axial images. In order to validate the results obtained by in vivo PET/CT imaging and to confirm the cardiac origin of the in vivo signal (n = 7), hearts from two MI-induced rats were also scanned ex vivo. (C) Photograph, (D) MRI only and (E) PET/MRI of the representative heart excised from rat, 7 days after coronary ligation, confirmed an augmented ⁶⁸Ga-NOTA-anti-MMR Nb uptake in the area close to the ligation site. ⁶⁸Ga-NOTA-anti-MMR Nb exhibited elevated uptake in scars from operation (blue arrowheads).