Table 3.
Multivariate analysis of the related factors for each type of CSVD.
| Variables | OR | 95% CI | P |
|---|---|---|---|
| DWMLs | |||
| Age | 1.082 | 1.027–1.140 | 0.003 |
| Hypertension | 1.629 | 0.671–3.957 | 0.281 |
| RPC density | 0.909 | 0.828–0.998 | 0.046 |
| Inside disc capillary density | 0.966 | 0.880–1.059 | 0.459 |
| PWMLs | |||
| Hypertensions | 3.019 | 1.196–7.626 | 0.019 |
| Age | 1.078 | 1.022–1.136 | 0.005 |
| DM | 1.498 | 0.556–4.031 | 0.424 |
| Hyperlipidemia | 1.753 | 0.693–4.432 | 0.236 |
| Inside disc capillary density | 0.999 | 0.914–1.091 | 0.975 |
| PVS | |||
| Hypertension | 1.354 | 0.526–3.485 | 0.530 |
| Age | 1.078 | 1.020–1.138 | 0.007 |
| RPC density | 0.881 | 0.779–0.995 | 0.041 |
| Inside disc capillary density | 0.928 | 0.836–1.032 | 0.167 |
| Peripapillary RNFL thickness | 0.964 | 0.907–1.023 | 0.225 |
| Lacunes | |||
| Hypertension | 3.156 | 1.348–7.392 | 0.008 |
| SRCP-parafoveal capillary density | 0.889 | 0.817–0.967 | 0.006 |
| SRCP-perifoveal capillary density | 1.012 | 0.892–1.147 | 0.856 |
| RPC density | 0.930 | 0.831–1.041 | 0.209 |
| Peripapillary RNFL thickness | 0.987 | 0.931–1.048 | 0.672 |
| CMB | |||
| Age | 1.037 | 0.990–1.086 | 0.128 |
| Hypertension | 1.231 | 0.479–3.167 | 0.666 |
| DM | 1.633 | 0.572–4.661 | 0.359 |
| Hyperlipidemia | 1.75 | 0.672–4.559 | 0.252 |
| Parafoveal RNFL thickness | 0.984 | 0.959–1.009 | 0.203 |
| Inside disc capillary density | 0.924 | 0.837–1.020 | 0.117 |
CSVD, cerebral small vessel disease; OR, odds ratio; CI, confidence interval; DWMLs, deep white matter lesions; PWMLs, paraventricular white matter lesions; DM, diabetes mellitus; PVS, perivascular spaces; RPC, radial peripapillary capillary; SRCP, superficial retinal capillary plexuses; CMB, cerebral microbleed; RNFL, retinal nerve fiber layer.