Table 1.
Baseline Characteristics of Patients in the Study
| Characteristics | China (n = 232) | Japan (n = 255) | Korea (n = 418) | P-value |
|---|---|---|---|---|
| Age at enrollment (yr) | 38.8 ± 14.2 | 43.2 ± 13.7 | 40.8 ± 15.3 | 0.001 |
| Disease duration (yr) | 4.1 ± 4.4 | 10.8 ± 8.2 | 7.0 ± 6.2 | < 0.001 |
| Male sex | 143 (61.6) | 129 (50.6) | 269 (64.5) | 0.001 |
| Comorbidities | 40 (17.2) | 115 (45.1) | 124 (29.7) | < 0.001 |
| SCCAI | 5.1 ± 4.2 | 0.7 ± 1.5 | 1.9 ± 2.1 | < 0.001 |
| HBI score | 3.8 ± 2.5 | 2.3 ± 2.6 | 2.3 ± 2.3 | < 0.001 |
| Active disease at enrollment | 109 (47.0) | 46 (18.0) | 53 (12.7) | < 0.001 |
| Current medications | ||||
| Steroid | 54 (23.3) | 26 (10.2) | 40 (9.6) | < 0.001 |
| Thiopurine | 45 (19.4) | 106 (41.6) | 135 (32.4) | < 0.001 |
| Tacrolimus | 0 | 8 (3.1) | 0 | < 0.001 |
| Anti-TNFs | 51 (22.1) | 59 (23.1) | 129 (30.9) | 0.018 |
| Previous surgery related with IBD | 52 (22.4) | 23 (9.0) | 76 (18.2) | < 0.001 |
| Previous admission related with IBD | 222 (95.7) | 90 (35.3) | 208 (49.9) | < 0.001 |
Values are presented as mean±standard deviation or number (%). Active disease was defined as HBI ≥5 for Crohn’s disease and SCCAI ≥5 for ulcerative colitis.
SCCAI, Simple Clinical Colitis Activity Index; HBI, Harvey-Bradshaw index; TNF, tumor necrosis factor; IBD, inflammatory bowel disease.