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Summary of Adverse Events
| Adverse events | No. (%) | Duration after initiation of indigo naturalis (day) |
|---|---|---|
| Mild adverse events | ||
| Headache | 8 (24) | 1–14 |
| Liver dysfunction | 5 (15) | 14–41 |
| Mild epigastric pain/abdominal pain | 5 (15) | 1–28 |
| Renal dysfunction | 1 (3) | 203 |
| Severe adverse events | ||
| Acute colitis | 3 (9) | 25–258 |
| Infectious colitis | 1 (3) | 49 |
| Intussusception | 1 (3) | 25 |
| Appendicitis | 1 (3) | 270 |
| Portal vein thrombosis | 1 (3) | 55 |
