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. 2022 Mar 21;9(5):622–632. doi: 10.1002/acn3.51542

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© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Patient selection, objectives, and experiment outlines of 3 independent cohorts. Cohort 1 aims to analyze NfL cross‐sectionally across disease diagnosis and severity categories. In cohort 2, the objective was to analyze NfL levels in critically ill COVID‐19 patients, longitudinally at three different timepoints (T1, T2, and T3: collected averagely at 5‐ to 10‐day interval, within 30 days of hospitalization). Observed additional prognostic value of NfL with traditional demographic factors (age and gender) from cohorts 1 and 2, was independently validated in cohort 3. NfL, neurofilament light chain; COVID‐19, coronavirus disease 19. This figure was generated using BioRender.com software. [Colour figure can be viewed at wileyonlinelibrary.com]