TABLE 1.
Clinical feature | Patient 1 | Patient 2 | Patient 3 |
---|---|---|---|
Demographic profile | 41-year-old woman | 37-year-old man | 33-year-old man |
HIV diagnosis status | Known to be living with HIV | Known to be living with HIV | Newly diagnosed HIV |
ART status | ART-naive | Second-line ART | Recently started first-line ART |
CD4 count (cells/μL) | 11 | 7 | 13 |
TB status | History of TB 10 years prior. Negative WHO TB symptom screen. |
History of TB four times prior and presented with TB symptoms. | No known history of TB. Negative WHO TB symptom screen. |
AlereLAM result | Positive Grade: 4+ |
Positive Grade: 4+ |
Positive Grade: 4+ |
Mycobacterial testing | Sputum: NTM† Urine: NTM† Blood: M. avium |
Sputum: M. kansasii Urine: M. kansasii |
Blood: M. avium |
Treatment received‡ | RHZE | RHZE followed by RHZE + Azithromycin | RHZE followed by RHE + Azithromycin |
Outcome | Died 3 months after presentation | Died 24 months after presentation | Died 17 months after presentation |
AlereLAM, Alere Determine-tuberculosis lipoarabinomannan assay; ART, antiretroviral therapy; NTM, non-tuberculous mycobacteria; TB, tuberculosis; WHO, World Health Organization.
, No further identification was conducted by laboratory;
, R = Rifampicin; H = Isoniazid; Z = Pyrazinamide; E = Ethambutol.