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. Author manuscript; available in PMC: 2022 May 9.
Published in final edited form as: Cell Host Microbe. 2022 Jan 19;30(2):260–272.e5. doi: 10.1016/j.chom.2021.12.008

Figure 7: In vitro treatment of an SIC reveals resistance and resilience in the Bacteroides genus.

Figure 7:

A) Bacteroides dynamics in vivo consist of B. vulgatus dominance during treatment and the recovery of several species after treatment. Data are the mean log10(relative abundance) at the ASV level across two SD mice: Bacteroides ovatus (Bo), B. vulgatus (Bv), B. uniformis (Bu), B. caccae (Bc), B. intestinalis (Bi), B. fragilis (Bf), and B. thetaiotaomicron (Bt). Other Bacteroides are shown in shades of grey.

B,C) Bacteroides survival and recovery in vivo can be respectively explained by resistance and resilience characteristics of the Pre-SD SIC in vitro during continuous treatment (B) or one round of treatment followed by two rounds of recovery (C). Data are the mean log10(relative abundance) of two replicates during one round of ciprofloxacin treatment and two rounds of recovery at the ASV level. Thick lines highlight Bacteroides ASVs that show resistance (B) or resilience (C) at the highest concentration that they display the behavior.