Table 1.
Differences across biomarker/clinical groups in demographic and Alzheimer's disease‐related measures.
| Ptau‐/Asym | Ptau+/Asym | Ptau‐/Sym | Ptau+/Sym | Total sample | Statistic | |||
|---|---|---|---|---|---|---|---|---|
| Ptau 217 | N | 119 (40%) | 54 (18%) | 60 (20%) | 67 (22%) | 300 | ‐ | |
| Age mean (SD) yrs | 80.75 (6.36) | 81.41 (6.15) | 82.00 (6.36) | 84.13 (6.51) | 81.87 (6.45) | F = 4.17, p = 0.006 | ||
| N (%) women | 81 (68%) | 31 (57%) | 42 (70%) | 46 (69%) | 200 (66.7%) | Χ2 = 2.60, p = 0.45 | ||
| Race/ethnicity N (%) | White N (%) | 46 (39%) | 18 (33%) | 14 (23%) | 22 (33%) | 100 (33.3%) | Χ2 = 5.90, p = 0.43 | |
| Black N (%) | 38 (32%) | 17 (32%) | 20 (33%) | 25 (37%) | 100 (33.3%) | |||
| Hispanic N (%) | 35 (29%) | 19 (35%) | 26 (43%) | 20 (30%) | 100 (33.3%) | |||
| APOE, N (%) with at least one ε4 allele | 21 (18%) | 28 (52%) | 8 (13%) | 27 (40%) | 84 (28%) | Χ2 = 32.99, p < 0.001 | ||
| Aβ42/Aβ40 mean (SD) concentration | 0.060 (0.01) | 0.057 (0.01) | 0.63 (0.02) | 0.057 (0.01) | 0.059 (0.01) | F = 2.39, p = 0.06 | ||
| T‐tau mean (SD) concentration, pg./mL | 4.63 (1.91) | 5.54 (2.39) | 4.58 (2.05) | 5.24 (2.08) | 4.92 (2.09) | F = 3.40, p = 0.01 | ||
| NfL mean (SD) concentration, pg./mL | 27.53 (19.12) | 38.45 (41.99) | 35.57 (30.81) | 38.43 (18.07) | 33.48 (27.25) | F = 3.52, p = 0.01 | ||
| Cognition mean (SD) standard score | Memory | 0.46 (0.54) | 0.32 (0.57) | −0.69 (0.67) | −0.89 (0.70) | −0.07 (0.85) | F = 92.73, p < 0.001 | |
| Language | 0.52(0.51) | 0.55 (0.56) | −0.41 (0.60) | −0.24 (0.50) | 0.17 (0.68) | F = 60.21, p < 0.001 | ||
| Speed/executive function | 0.44 (0.80) | 0.51 (0.69) | −0.59 (1.08) | −0.49 (1.06) | 0.12 (0.99) | F = 23.71, p < 0.001 | ||
| Visuospatial function | 0.58 (0.43) | 0.54 (0.56) | −0.18 (0.61) | −0.03 (0.62) | 0.30 (0.63) | F = 37.15, p < 0.01 | ||
| Cortical thickness mean (SD) mma | 2.60 (0.14) | 2.57 (0.14) | 2.53 (0.14) | 2.52 (0.16) | 2.57 (0.14) | F = 3.50, p = 0.016 | ||
| Ptau 181 | N | 123 (41%) | 49 (16%) | 68 (23%) | 59 (20%) | 300 | ‐ | |
| Age mean (SD) yrs | 80.40 (6.26) | 82.33 (6.25) | 82.34 (6.56) | 84.03 (6.37) | 81.87 (6.47) | F = 4.68, p = 0.08 | ||
| Race/ethnicity N (%) | White N (%) | 45 (36.7) | 19 (39) | 18 (26.5) | 18 (30.5) | 100 (33.3) | Χ2 = 5.53, p = 0.47 | |
| Black N (%) | 39 (32) | 15 (31) | 21 (31) | 24 (41) | 100 (33.3) | |||
| Hispanic N (%) | 39 (32) | 15 (31) | 29 (42.6) | 17 (29) | 100 (33.3) | |||
| APOE, N (%) with at least one ε4 allele | 26 (21) | 22 (45) | 12 (17.6) | 23 (39) | 83 (28) | Χ2 = 17.04, p = 0.001 | ||
| Aβ42/Aβ40 mean (SD) concentration | 0.060 (0.01) | 0.058 (0.01) | 0.062 (0.02) | 0.057 (0.01) | 0.059 (0.01) | F = 1.57, p = 0.196 | ||
| T‐tau mean (SD) concentration, pg./mL | 4.58 (1.88) | 5.75 (2.41) | 4.40 (1.68) | 5.54 (2.23) | 4.92 (2.09) | F = 7.21, p < 0.001 | ||
| NfL mean (SD) concentration, pg./mL | 26.84 (18.57) | 40.56 (43.87) | 32.51 (26.52) | 42.30 (21.75) | 33.46 (27.29) | F = 5.85, p < 0.001 | ||
| Cognition mean (SD) standard score | Memory | 0.44 (0.54) | 0.35 (0.58) | −0.72 (0.63) | −0.88 (0.75) | −0.07 (0.85) | F = 90.81, p < 0.001 | |
| Language | 0.49 (0.49) | 0.60 (0.62) | −0.37 (0.57) | −0.27 (0.53) | 0.17 (0.68) | F = 59.45, p < 0.001 | ||
| Speed/executive function | 0.41 (0.79) | 0.56 (0.71) | −0.59 (1.03) | −0.47 (1.11) | 0.12 (0.99) | F = 23.79, p < 0.001 | ||
| Visuospatial function | 0.55 (0.46) | 0.62 (0.51) | −0.16 (0.62) | −0.04 (0.61) | 0.30 (0.63) | F = 36.58, p < 0.001 | ||
| Cortical thickness mean (SD) mma | 2.60 (0.12) | 2.56 (0.18) | 2.54 (0.13) | 2.51 (0.16) | 2.57 (0.14) | F = 4.20, p = 0.006 | ||
The four groups: Ptau‐/Asym, Pta+/Asym, Ptau‐/Sym, and Ptau+/Sym, differed significantly by age, APOE‐4 allele frequency, total tau, NfL, and cortical thickness on MRI. Ptau+ regardless of their symptomatic status were similar with only slight differences in cortical thickness. There were no difference by sex/gender or race/ethnicity across the four groups.
a
Available for n = 223 participants.