Table 1.
Demographic and baseline characteristics of included subjects according to Helicobacter pylori status
| Characteristic | Total (n = 124) | H. pylori-negative (n = 40) | H. pylori-positive | p valuea | |
|---|---|---|---|---|---|
| Non-eradicated (n = 34) | Eradicated (n = 50) | ||||
| Age, yr | 61.43 ± 10.45 | 61.13 ± 10.14 | 62.82 ± 12.60 | 60.72 ± 9.14 | 0.651 |
| Age < 65 yr | 71 (57.3) | 25 (62.5) | 16 (47.1) | 30 (60.0) | 0.359 |
| Male sex | 72 (59.0) | 21 (52.5) | 24 (70.6) | 27 (55.6) | 0.219 |
| Current/ex-smoker | 59 (47.6) | 17 (42.5) | 20 (58.8) | 22 (44.0) | 0.302 |
| Current/ex-drinker | 75 (61.5) | 21 (52.5) | 22 (64.7) | 32 (64.0) | 0.454 |
| T2DM | 104 (83.9) | 31 (77.5) | 31 (91.2) | 42 (84.0) | 0.281 |
| Prediabetes | 20 (16.1) | 9 (22.5) | 3 (8.8) | 8 (16.0) | |
| Diabetes medication | 66 (51.6) | 20 (50.0) | 15 (44.1) | 24(48.0) | 0.878 |
| Metformin | 44 (35.5) | 13 (32.5) | 13 (38.2) | 18 (36.0) | 0.872 |
| Sulfonylurea | 34 (27.4) | 12 (30.0) | 8 (23.5) | 14 (28.0) | 0.818 |
| Othersb | 30 (24.2) | 8 (20.0) | 8 (23.5) | 14 (28.0) | 0.609 |
| Hypertension | 82 (66.1) | 28 (70.0) | 22 (64.7) | 32 (64.0) | 0.819 |
| Hyperlipidemia | 64 (51.6) | 17 (34.0) | 21 (61.8) | 26 (52.0) | 0.255 |
| A1C, % | 6.55 ± 0.08 | 6.52 ± 0.13 | 6.58 ± 0.14 | 6.55 ± 0.14 | 0.961 |
| TG, mg/dL | 150.52 ± 7.85 | 148.97 ± 15.42 | 162.89 ± 16.48 | 143.79 ± 10.71 | 0.609 |
| HDL-C, mg/dL | 48.30 ± 1.19 | 49.34 ± 2.63 | 49.56 ± 2.20 | 46.73 ± 1.58 | 0.536 |
| LDL-C, mg/dL | 100.11 ± 2.67 | 105.78 ± 4.93 | 100.81 ± 4.94 | 94.70 ± 4.04 | 0.215 |
| TC, mg/dL | 179.76 ± 3.77 | 188.69 ± 6.21 | 181.44 ± 8.42 | 172.08 ± 5.34 | 0.173 |
| SBP, mmHg | 134.84 ± 2.19 | 135.57 ± 4.63 | 133.73 ± 3.12 | 135.00 ± 3.33 | 0.946 |
| DBP, mmHg | 76.96 ± 1.12 | 80.19 ± 1.83 | 77.43 ± 2.27 | 73.45 ± 1.64 | 0.035c |
| BMI, kg/m2 | 25.24 ± 0.30 | 25.29 ± 0.44 | 25.57 ± 0.69 | 24.97 ± 0.45 | 0.708 |
| FPG, mg/dL | 130.44 ± 4.33 | 128.00 ± 8.14 | 135.35 ± 7.67 | 128.68 ± 6.86 | 0.763 |
| MS | 61 (50.0) | 18 (46.2) | 18 (55.0) | 25 (50.0) | 0.777 |
Values are presented as mean ± standard error or number (%).
T2DM, type 2 diabetes mellitus; A1C, glycated hemoglobin A1c; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; FPG, fasting plasma glucose; MS, metabolic syndrome.
Student’s t test and analysis of variance (ANOVA) were used for continuous data, and chi-square test was used for categorical variables.
Other classes of the diabetes medication, including meglitinide, thiazolidinedione, dipeptidyl peptidase-4 inhibitor, α-glucosidase inhibitor, insulin, and sodium-glucose cotransporter 2 inhibitor.
Statistically significance (p < 0.05).