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. 2022 Mar 30;91(6):772–781. doi: 10.1002/ana.26350

FIGURE 2.

FIGURE 2

COVID‐19‐associated alterations in NDEV levels of proteins in mitochondrial ion channels and translocators. Each point represents the value for one study participant after CD81 normalization. The horizontal line depicts mean value. Statistical significance of the difference in level for each group was calculated relative to Ctl values by an unpaired t test; NS, not significant; +, p <0.05; *, p <0.01; **, p <0.001. The significance (p values) of differences between participants who had PASC w/ NP and those who had PASC w/o NP and between participants who had PASC w/ NP and those who had PASC w/ severe NP, respectively, were: NS and <0.05 for voltage‐dependent anion‐selective channel protein 1 (VDAC1) (A); <0.05 and <0.001 for mitochondrial calcium uniporter protein (MCU) (B); <0.05 and <0.05 for mitochondrial Na+/Ca++ exchanger (NCLX) (C); <0.01 and <0.01 for leucine zipper EF‐hand containing transmembrane 1 protein (LETM1) (D); NS and NS for N‐methyl‐D‐aspartate receptor 1 (NMDAR1) (E); and NS and NS for translocator protein (TSOP) (F). NP = neuropsychiatric abnormalities.