Figure 1.
Schematic of Prime-Pull-Keep Therapeutic Vaccine (PPK Vaccine). The PPK vaccine is designed to boost Neutralizing IgG/IgA antibodies (Abs) and boost the number and function of antiviral CD4+ and CD8+ TRM cells within the cervico genital muco-cutaneous [CGMC, (1)] and dorsal root ganglia [DRG (2)] tissues. The PPK vaccine is expected to help STOP the virus reactivation from latently infected DRG, virus shedding and virus replication in CGMC, thus curing or reducing recurrent genital herpes disease. *, represent virus.