Scheme 1. Synthesis of triazoles 4–9 and 12–15. Reagents and conditions: (a) NaOMe, MeOH, rt; (b) alkyne, CuI, DIPEA, MeCN, 50 °C; (c) (i). 1-{[2-(Trimethylsilyl)ethoxy]methyl}-4-[2-(trimethylsilyl)ethynyl]-1H-imidazole, CuI, DIPEA, MeCN, 50 °C; (ii). BF₃OEt₂, CH₂Cl₂, rt; (d) methyl thioglycolate, BF₃ OEt₂, CH₂Cl₂, rt; (e) (i). Alkyne, CuI, DIPEA, MeCN, 50 °C; (ii). NaOMe, MeOH, rt; (iii). LiOH, THF : H₂O (9 : 1), rt. Tol = p-methylphenyl.