K d (μM) values for triazoles 4–9 and 12–15 and references 16–17 determined by competitive fluorescence polarization.
Galectin-1 | Galectin-3 | Galectin-3/galectin-1 | |
---|---|---|---|
4 | 370 ± 30 | 980 ± 60 | 2.6 |
5 | 120 ± 7 | 250 ± 20 | 2.1 |
6 | 61 ± 4 | 180 ± 10 | 3.0 |
7 | 47 ± 2 | 200 ± 10 | 4.3 |
8 | 47 ± 3 | 220 ± 10 | 4.7 |
9 | 140 ± 7 | 330 ± 20 | 2.4 |
12 | 58 ± 4 | 200 ± 7 | 3.4 |
13 | 43 ± 2 | 280 ± 7 | 4.5 |
14 | 62 ± 2 | 540 ± 30 | 8.7 |
15 | 180 ± 9 | 430 ± 20 | 2.4 |
16 | 1100 15 | 230 15 | 0.2 |
17 | 430 ± 40 | 1800 ± 100 | 4.2 |