FIGURE 7.

Iron overload, lipid peroxidation, and neuronal damage in the hippocampus of the CCI-induced memory impairment rat model. (A,D): Compared with sham rats, the number of Nissl positive bodies in the hippocampus of CCI-induced memory impairment was decreased, and the morphology of Nissl positive bodies was obviously changed. (B): DAB-enhanced Perls stain showed Perls positive iron deposits in the hippocampus of CCI-induced memory impairment rat model. (C): Iron content in hippocampus and plasma were significantly increased in the hippocampus of CCI-induced memory impairment. (E–H): showing the lipid peroxidation in the hippocampus of CCI-induced memory impairment as the following results: significantly increased ROS level (E) and MDA content (F), significantly downregulated SOD activity (G) and GSH content (H) via corresponding detection kits. n = 3–6 rats/group, *p < 0.05, **p < 0.01 vs sham group. The student’s t test was used for comparisons.