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. 2022 Apr 25;10:843297. doi: 10.3389/fcell.2022.843297

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Copyright © 2022 Tang, Liu, Zhu, Chen, Sun, Zhang, Zhao, Wu, Fei, Ye and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ferrostatin-1 significantly inhibited the ferroptotic damage. (A,B): Representative scatter diagram showing the iron content of hippocampus and plasma in these above groups. (C–F): Representative scatter diagram showing the levels of ROS (C), MDA (D), GSH (E), and SOD (F) of hippocampus in these above groups. (G–J): Representative scatter diagram showing validation of gene marker mRNA levels in the hippocampus for ferroptosis. n = 3–6 rats/group. *p < 0.05, **p < 0.01, ***p < 0.001 vs sham group or CCI + Fer-1 group. One-way ANOVA test was used for comparisons.