TABLE 2.
Summary relative risk (RR) with 95% confidence interval (CI) of the association between high dietary acrylamide exposure and site-specific cancer.
| All | Never smoker | Ever-smoker | ||||||||||
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| Type of cancer | N | RR | (95% CI) | I2 | N | RR | (95% CI) | I2 | N | RR | (95% CI) | I2 |
| Oral cavity | 2 | 0.99 | (0.67–1.46) | 16.9 | 1 | 1.06 | (0.84–1.33) | – | – | |||
| Oro and hypopharynx | 1 | 0.61 | (0.33–1.12) | – | – | – | – | – | ||||
| Esophageal | 5 | 1.05 | (0.85–1.29) | 25.5 | 3 | 1.22 | (0.77–1.95) | 36.2 | – | |||
| Stomach | 2 | 0.92 | (0.82–1.05) | 0.0 | 1 | 1.43 | (0.92–2.23) | – | 1 | 0.96 | (0.60–1.53) | – |
| Colorectal | 7 | 0.94 | (0.87–1.02) | 0.0 | 2 | 0.89 | (0.46–1.73) | 74.6 | 2 | 0.90 | (0.64–1.26) | 0.0 |
| Colon | 4 | 0.96 | (0.85–1.09) | 15.9 | 1 | 1.21 | (0.86–1.70) | – | – | |||
| Rectal | 4 | 0.99 | (0.84–1.18) | 0.0 | 1 | 1.48 | (0.77–2.84) | – | – | |||
| Pancreatic | 5 | 0.88 | (0.77–1.02) | 0.0 | 4 | 0.90 | (0.74–1.10) | 2.9 | 4 | 0.82 | (0.65–1.03) | 0.0 |
| Liver | 1 | 1.08 | (0.87–1.34) | – | 1 | 1.15 | (0.85–1.56) | – | 1 | 1.07 | (0.80–1.43) | – |
| Head and neck | 1 | 0.74 | (0.50–1.09) | – | – | – | – | – | ||||
| Laryngeal | 2 | 1.10 | (0.79–1.54) | 0.0 | 1 | 0.82 | (0.53–1.28) | – | – | |||
| Lung | 2 | 0.91 | (0.64–1.28) | 83.1 | 2 | 0.92 | (0.73–1.17) | 0.0 | 2 | 1.16 | (1.03–1.31) | 0.0 |
| Thyroid | 1 | 1.33 | (0.70–2.53) | - | 1 | 1.03 | (0.84–1.26) | – | – | |||
| Bladder/Urothelial | 3 | 0.89 | (0.74–1.07) | 0.0 | 3 | 0.85 | (0.45–1.59) | 72.5 | 3 | 0.94 | (0.74–1.21) | 0.0 |
| Renal | 7 | 1.08 | (0.93–1.26) | 19.4 | 4 | 1.13 | (0.87–1.45) | 0.0 | 3 | 1.10 | (0.74–1.64) | 0.0 |
| Prostatic | 7 | 1.00 | (0.93–1.07) | 0.0 | 4 | 0.98 | (0.88–1.10) | 0.0 | 4 | 0.96 | (0.83–1.10) | 0.0 |
| Lymphoma | 2 | 1.08 | (0.95–1.22) | 11.5 | 2 | 0.99 | (0.68–1.44) | 45.6 | 2 | 1.14 | (0.81–1.62) | 0.0 |
| Multiple myeloma | 2 | 0.97 | (0.58–1.64) | 63.6 | 2 | 0.98 | (0.49–1.96) | 50.5 | 1 | 0.52 | (0.21–1.28) | – |
| Melanoma | 1 | 1.18 | (0.72–1.96) | – | 1 | 1.14 | (0.75–1.75) | – | – | |||
| Brain | 1 | 0.87 | (0.54–1.41) | – | 1 | 0.87 | (0.46–1.64) | – | – | |||
Results are shown for all subjects and for never smokers and ever smokers separately.