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BLIP and BLIP peptide Kis for various β-lactamases
| β-Lactamase |
Ki (μM)
|
||||
|---|---|---|---|---|---|
| BLIP | Oxidized BP46-51 | Reduced BP46-51 | BP41-50 | Protein kinase C substrate | |
| TEM-1 | 0.0003 | 603 | 488 | 359 | — |
| SHV-1 | 1.0 | 680 | 420 | 458 | — |
| PC-1 | —a | — | 1,400 | — | — |
| IMP-1 | — | — | NDb | — | — |
| P99 | — | — | 135 | — | — |
| OXA-10 | — | — | — | — | — |
—, for those peptide-enzyme combinations for which there was no detectable inhibition, peptide was tested up to 1,000 μM.
ND, not determined.
