Table 1.
Vehicle | Luseogliflozin | |
---|---|---|
Number | 9 | 10 |
Food intake (g/day) | 5.0 | 5.0 |
Heart weight index | 8.9 ± 0.5 | 8.6 ± 0.6 |
Kidney weight index | 18.7 ± 1.4 | 14.7 ± 1.6** |
Liver weight index | 142.6 ± 11.4 | 108.3 ± 15.9** |
Visceral fat weight index | 85.7 ± 5.1 | 88.7 ± 5.5 |
Pulse rate (/minute) | 597 ± 63 | 638 ± 38 |
Systolic blood pressure (mmHg) | 127 ± 23 | 127 ± 23 |
HbA1c (%) | 12.4 ± 0.3 | 7.8 ± 0.6** |
Plasma glucose (mg/dL) | 564 ± 49 | 255 ± 46** |
Plasma insulin (ng/mL) | 0.3 ± 0.2 | 0.7 ± 0.6 |
Plasma total cholesterol (mg/dL) | 234 ± 32 | 230 ± 42 |
Plasma HDL cholesterol (mg/dL) | 139 ± 27 | 140 ± 29 |
Plasma triglycerides (mg/dL) | 108 ± 38 | 108 ± 58 |
Mean ± standard deviation. HDL, high-density lipoprotein; HbA1c, glycated hemoglobin. *p < 0.05, **p < 0.01 vs. Vehicle.