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. Author manuscript; available in PMC: 2022 May 9.
Published in final edited form as: ACS Infect Dis. 2021 Apr 23;7(6):1795–1808. doi: 10.1021/acsinfecdis.1c00101

Figure 8.

Figure 8.

Biofilm inhibition capability of C10-KR8d in a catheter-associated biofilm model challenged with S. aureus USA300 LAC. (A) A single dose treatment with C10-KR8d (250 μg) into the implanted catheter lumen and surrounding tissues (50 μL/site; into lumen, four sides of the catheter) of mice (n=4). The catheter alone animal group without bacterial infection was included as a control. The CFU of each mouse represents individual points and error bars represents the deviation within the experimental group. Starred CFU differences (*) with p <0.05 were considered statistically significant within groups as determined by the Mann-Whitney test (GraphPad Prism 7). ELISA quantification of the levels of MCP-1 (B), IL-17A (C), IL-10 (D), and TNF-α (E) in the surrounding tissues of catheters embedded in mice with and without treatment with C10-KR8d.