Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 25;15:832490. doi: 10.3389/fnmol.2022.832490

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Groemer, Triller, Zeilhofer, Becker, Eulenburg and Becker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Region-specific expression of GlyR mRNA at the spinal level. GlyR mRNA expression was investigated in dorsal root ganglia (drg), superficial dorsal horn (sfdh) and ventral horn of the spinal cord (vsc). For GlyRβ, multiple bands in tissues derived from Glrb^spa/spa animals correspond to truncated transcripts generated by exon skipping (413 bp, transcript lacks exons 4 and 5; 643 bp, transcript lacks exon 5); the upper band represents the full-length transcript (726 bps; Mülhardt et al., 1994). No GlyRα subunit RNA could be detected in DRGs, whereas GlyRβ was expressed. Transcripts encoding GlyRα1–4 and GlyRβ were found in the superficial dorsal horn (sfdh; sizes: α1: 831 bp; α2: 1,152 bp; α3: 1,158 bp; α4: 509 bp; β - full length: 726 bp). The predominant subunit in the ventral spinal cord (vsc) was GlyRα1 (low signal). In Glrb^spa/spa mice, the regional distribution of glycine receptor mRNAs remained unchanged.