Table 1.
Curve fit parameters for histograms of log10(variant-TSS) distances from several studies. Initial fits were from log10 = 0 to observed minimum in the histogram, as presented in the table. Final fit included our trans model (methods) and started from the values generated from the initial fits. In all cases, the Kolmogorov–Smirnov test favored the Weibull distribution over the Gaussian distribution
| Study | Initial cis Log10 dist cutoff (cis < X) | Initial fit Weibull shape parameter κ | Initial fit Weibull scale parameter λ |
Weibull only Kolmogorov–Smirnov p-value | Gaussian only Kolmogorov–Smirnov p-value |
Initial Weibull fraction | Final fit (Weibull + trans) shape parameter k (SE) |
Final fit (Weibull + trans) scale parameter l (SE) | Final fit (Weibull + trans) Weibull fraction (SE) | Final fit (Weibull + trans), Kolmogorov–Smirnov p-value |
Alternate final fit (Gaussian + Trans) fit, Kolmogorov–Smirnov p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Pietzner pQTL | 5.75 | 6.4803 | 4.4428 | 0.1018 | 0.0000 | 0.7835 | 6.777 (0.211) | 4.478 (0.024) | 0.799 (0.013) | 0.3645 | 0.0054 |
| deCode pQTL | 6 | 5.6487 | 4.4515 | 0.0089 | 0.0000 | 0.6462 | 6.192 (0.315) | 4.466 (0.043) | 0.665 (0.017) | 0.0223 | 0.0044 |
| Eqtlgen | NA | NA | NA | 7.255E-07 | < 2.2e-16 | 1.0000 | 7.375 (0.054) | 4.700 (0.006) | 1.0 (NA) | NA | NA |
| Metabolite QTLs | 6.5 | 6.2855 | 5.2105 | 0.5689 | 0.4698 | 0.3095 | 4.262 (1.881) | 5.544 (0.708) | 0.346 (0.080) | 0.0183 | 0.0142 |