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. 2022 May 9;12:7570. doi: 10.1038/s41598-022-11230-8

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Receptor numbers on MDM are differentially affected by ALFQ. Primary human monocytes were differentiated into MDM following culture with M-CSF media. At day 4 post-culture, the cells were treated with ALF55 or ALFQ for 24 h. Untreated MDM (no adjuvant) cultures served as controls. Cells were harvested, stained, and the number of MHC-I, MHC-II, CD80, CD86, CD16, CD32 and Siglec-1 receptors was quantified by flow cytometry. Scatter dot plots show the number of the indicated cell receptors on the gated CD14⁺MDM that were not treated with any adjuvant (black circles) or were treated with ALF55 (brown circles) or ALFQ (magenta circles) for triplicate wells for the four donors shown in Fig. 4. Data are representative of two independent experiments. P values indicate statistical differences by One-way ANOVA.