FIG. 5.

VVC in immunosuppressed rats treated with GW471558 at 10 mg/kg. PAS staining was used. (a) C. albicans was not observed in treated rats. Ulceration of the covering vaginal epithelium with fibrin deposits in the lumen (arrowhead) and an important inflammatory response of the lamina propria (asterisk) were observed. The transition between mucosal ulcera and adjacent vaginal epithelium is shown by the arrow. Magnification, ×100. (b) Regenerative changes of the vaginal epithelium were observed in this area (arrows). Also observed was the development of a granulation tissue (asterisk) in the ulcerate lamina propria. Magnification, ×400.