. 2001 Dec;45(12):3304–3309. doi: 10.1128/AAC.45.12.3304-3309.2001

TABLE 2.

Therapeutic efficacies of GW471552 and GW471558 against experimental VVC in rats^a

Dose (mg/kg)	No. of infected animals/ total (% infected) after treatment	Log CFU/sample (mean ± SD)^b	% Reduction of CFU compared to control
Control	6/6 (100)	4.9 ± 0.3
GW471552
1	6/6 (100)	4.6 ± 0.2	49.88
5	2/6 (33)	1.7 ± 0.2^*	99.94
10	0/6 (0)	NOD^*	100
GW471558
1	3/6 (50)	2.6 ± 0.1^*	99.50
5	0/6 (0)	NOD^*	100
10	0/6 (0)	NOD^*	100

Rats were intravaginally infected with 10⁸ C. albicans 4711E cells/ml. Compounds were administered every 4 h for 3 consecutive days.

NOD, no organisms detected. *, P < 0.05 (versus the control treatment). The limit of detection was 40 CFU/sample.