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. 2001 Dec;45(12):3304–3309. doi: 10.1128/AAC.45.12.3304-3309.2001

TABLE 2.

Therapeutic efficacies of GW471552 and GW471558 against experimental VVC in ratsa

Dose (mg/kg) No. of infected animals/ total (% infected) after treatment Log CFU/sample (mean ± SD)b % Reduction of CFU compared to control
Control 6/6 (100) 4.9 ± 0.3
GW471552
  1 6/6 (100) 4.6 ± 0.2 49.88
  5 2/6 (33) 1.7 ± 0.2* 99.94
 10 0/6 (0) NOD* 100
GW471558
  1 3/6 (50) 2.6 ± 0.1* 99.50
  5 0/6 (0) NOD* 100
 10 0/6 (0) NOD* 100
a

Rats were intravaginally infected with 108 C. albicans 4711E cells/ml. Compounds were administered every 4 h for 3 consecutive days. 

b

NOD, no organisms detected. *, P < 0.05 (versus the control treatment). The limit of detection was 40 CFU/sample.