Figure 2.

Three types of response patterns based on the radiological evaluation of existing target lesions per RECIST 1.1 criteria. (a) Typical response patterns include complete response, partial response, stable disease, and progressive disease by measuring the variation in the sum of the longest diameters of the target lesions. (b) General atypical response patterns include DeR, PsPD, and HPD that have concordant progressive lesions and can be captured when two consecutive assessments are completed. HPD is often defined as a greater than 50% increase in the tumor burden, twofold or more increase in the tumor growth ratio or a tumor growth kinetics ratio during treatment with immunotherapy compared with that observed before immunotherapy. (c) DR is a specific mixed or heterogeneous response pattern. Unlike general atypical responses, DR is captured at a single time point for different target lesions with inverse responses to immunotherapy.

IO, immunotherapy; SLD, sum of the longest diameters; TL1, target lesion 1; TL2, target lesion 2.