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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Genes Brain Behav. 2021 Oct 22;20(8):e12774. doi: 10.1111/gbb.12774

FIGURE 2.

FIGURE 2

Genome-wide significant QTL on chromosome 11 near Cyfip2 underlying variation in sensitized methamphetamine-induced maximum speed. Mice were treated on Day(D) 1 and D2 with saline (i.p.) and on D3, D4 and D5 with methamphetamine and behavioral activity was recorded over 30 min. (A) Genome-wide significant QTL on chromosome 11 for maximum speed following the second methamphetamine injection on D4 and following the third methamphetamine injection on D5. Solid horizontal lines for panels A and B indicate significance thresholds for each phenotype (p < 0.05). (B) Chromosome 11 QTL plot for maximum speed on D1 through D5. (C) Effect plot of maximum speed as a function of Genotype at the peak locus for maximum speed on D1 through D5. J, homozygous for B6J allele; BN, heterozygous; N, homozygous for B6NJ allele