TABLE 2.

Enrichment analysis of genes correlated with Gabra2 transcript levels in F2 mice (n = 23; r ≤ −0.5 or r ≥ +0.5; p ≥ 0.015)

GO: Biological process
Term	GO #	Overlap	p-value	Adj. p	Z-score	Combined Score	Genes
Synaptic transmission, GABAergic	51,932	3/12	7.83E–05	0.05354	−2.45	23.13	GABRA2;GABRE;GABRG3
GABA signaling pathway	7214	3/20	3.89E–04	0.132938	−2.06	16.21	GABRA2;GABRE;GABRG3
L-amino acid transport	15,807	3/26	8.59E–04	0.195793	−2.22	15.68	PRAF2;SLC3A2;SLC38A5
Regulation of postsynaptic membrane potential	60,078	3/34	1.89E–03	0.257775	−1.51	9.49	GABRA2;GABRE;GABRG3
Chemical synaptic transmission, postsynaptic	99,565	3/34	1.89E–03	0.257775	−1.45	9.09	GABRA2;GABRE;GABRG3
GO: Cellular component
Term	GO #	Overlap	p-value	Adj. p	Z-score	Combined Score	Genes
GABA-A receptor complex	1,902,711	3/20	3.89E–04	0.023457	−2.19	17.20	GABRA2;GABRE;GABRG3
dendrite membrane	32,590	3/21	4.51E–04	0.023457	−2.78	21.38	GABRA2;GABRE;GABRG3
germ plasm	60,293	2/14	4.49E–03	0.123421	−2.36	12.75	TDRD1;SNRPG
Cytoskeleton	5856	10/521	4.75E–03	0.123421	−1.58	8.45	BCAS3;ACTR1A;EDA;MYOT; MVP;SHROOM2;MYOZ3; NPM3;S100A9;MDN1
P granule	43,186	2/17	6.61E–03	0.137495	−2.35	11.81	TDRD1;SNRPG
GO: Molecular function
Term	GO #	Overlap	p-value	Adj. p	Z-score	Combined Score	Genes
Benzodiazepine receptor activity	8503	3/11	5.90E–05	0.009565	−2.81	27.34	GABRA2;GABRE;GABRG3
GABA-gated chloride ion channel activity	22,851	3/13	1.01E–04	0.009565	−2.49	22.93	GABRA2;GABRE;GABRG3
Inhibitory extracellular ligand-gated ion channel activity	5237	3/16	1.95E–04	0.012288	−2.39	20.38	GABRA2;GABRE;GABRG3
Ligand-gated anion channel activity	99,095	3/19	3.32E–04	0.014028	−2.16	17.29	GABRA2;GABRE;GABRG3
GABA-A receptor activity	4890	3/20	3.89E–04	0.014028	−2.09	16.42	GABRA2;GABRE;GABRG3