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. 2022 Feb 28;17(10):2238–2246. doi: 10.4103/1673-5374.336871

Figure 2.

Figure 2

Effects of MSCs-EVs on OGD-induced microglial apoptosis.

(A) The viability of BV-2 cells, measured using CCK8, for OGD durations of 1, 3, and 5 hours followed by 24-hour reoxygenation. n = 6 per group. (B) The viability of BV-2 cells in the presence or absence of MSCs-EVs. Cells had undergone 3-hour OGD followed by 24-hour reoxygenation. n = 6 per group. (C) The viability of BV-2 cells with no EVs , with EVs (10 μg/mL), with EVs (10 μg/mL) and RNase A (20 μg/mL), with EVs (10 μg/mL) and 0.5% TritonX-100, and with EVs (10 μg/mL), 0.5% Triton X-100, and RNase A (20 μg/mL). Cells had undergone 3-hour OGD followed by 24-hour reoxygenation. Cells incubated under standard cell culture conditions formed the “control” group and were used to define 100 % cell survival. Graphs show the mean ± SD. All of the experiments were carried out on six independent samples. **P < 0.01, ***P < 0.001 (independent samples t-test) in A and B; *** P < 0.001 (one-way analysis of variance with Bonferroni correction) in C. EV: Extracellular vesicle; MSC: mesenchymal stromal cell; OGD oxygen-glucose deprivation.