FIG. 2.

(A) AUC_0–∞ at the three investigated dosage levels (0.5, 1, and 2 mg) after administration of single and multiple doses of micafungin (FK). Each bar represents the mean ± SEM of three rabbits. Note the absence of drug accumulation in plasma over time after multiple once-daily doses. (B) Plot of dose-normalized AUC after multiple once-daily doses with micafungin over 7 days versus dosage. The values for individual animals (squares) and the corresponding means (triangles) ± SEM are shown. The slope of the regression line is not significantly different from zero, indicating linear disposition in plasma over the investigated dosage range.