TABLE 1.

Single-dose compartmental pharmacokinetic parameters of micafungin in plasma^a

Drug dose (mg/kg)	Cmax (μg/ml)	Cmin (μg/ml)	AUC0–∞ (μg · h/ml)	Vp (liter/kg)	Vc (liter/kg)	VSS (liter/kg)	CLd (liter/h/kg)	CLt (liter/h/kg)	α-HL (h)	β-HL (h)
0.5	7.672 ± 1.495	<LLQ	5.68 ± 0.43	0.305 ± 0.026	0.04 ± 0.008	0.301 ± 0.025	0.267 ± 0.047	0.09 ± 0.007	0.071 ± 0.003	2.974 ± 0.109
1.0	13.073 ± 0.204	<LLQ	13.50 ± 1.56	0.251 ± 0.02	0.045 ± 0.000	0.296 ± 0.019	0.316 ± 0.008	0.077 ± 0.01	0.07 ± 0.002	3.2 ± 0.145
2.0	16.087 ± 1.725	<LLQ	21.96 ± 1.73	0.254 ± 0.006	0.089 ± 0.018	0.343 ± 0.014	0.428 ± 0.023	0.089 ± 0.01	0.325 ± 0.22	3.049 ± 0.269
P valueb	0.0113	NA	0.0005	0.9060	0.0407	0.2561	0.0255	0.5282	0.2566	0.7005

^aAll values represent the means ± SEMs for three rabbits. Abbreviations: V_p and V_c, volume of distribution in the peripheral and central compartment, respectively; CL_d, distributional clearance; α-HL, distributional half-life; β-HL, elimination half-life; NA, not applicable. The LLQ of the analytical assay was 0.1 μg/ml. 

^bP values for the comparison among dosage groups by ANOVA.