TABLE 2.
Multiple-dose compartmental pharmacokinetic parameters of micafungin in plasmaa
| Drug dose (mg/kg) | Cmax (μg/ml) | Cmin (μg/ml) | AUC0–∞ (μg · h/ml) | Vp (liter/kg) | Vc (liter/kg) | VSS (liter/kg) | CLd (liter/h/kg) | CLt (liter/h/kg) | α-HL (h) | β-HL (h) |
|---|---|---|---|---|---|---|---|---|---|---|
| 0.5 | 9.443 ± 1.83 | <LLQ | 6.22 ± 0.97 | 0.226 ± 0.053 | 0.031 ± 0.004 | 0.258 ± 0.057 | 0.182 ± 0.085 | 0.075 ± 0.012 | 0.07 ± 0.006 | 2.988 ± 0.424 |
| 1.0 | 18.093 ± 1.19 | <LLQ | 14.16 ± 2.11 | 0.215 ± 0.02 | 0.029 ± 0.002 | 0.245 ± 0.02 | 0.235 ± 0.009 | 0.067 ± 0.01 | 0.063 ± 0.002 | 3.178 ± 0.192 |
| 2.0 | 19.165 ± 0.305 | <LLQ | 22.29 ± 1.76 | 0.223 ± 0.011 | 0.090 ± 0.011 | 0.313 ± 0.007 | 0.393 ± 0.043 | 0.083 ± 0.009 | 0.101 ± 0.011 | 3.347 ± 0.447 |
| P valueb | 0.0096 | NA | 0.0040 | 0.9774 | 0.0002 | 0.5479 | 0.0306 | 0.9227 | 0.0222 | 0.7995 |
a
All values represent the means ± SEMs of 3 rabbits each. Abbreviations: Vp and Vc, volume of distribution of the peripheral and central compartment, respectively; CLd, distributional clearance; α-HL, distributional half-life; β-HL, elimination half-life; NA, not applicable. The LLQ of the analytical assay was 0.1 μg/ml.
b
P values for the comparison among dosage groups by ANOVA.