TABLE 3.
Tissue micafungin concentrations after multiple doses over 8 days
| Drug dose (mg/kg) | Micafungin concn in tissue or body fluida:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Lung (μg/g) | Liver (μg/g) | Spleen (μg/g) | Kidney (μg/g) | Brain (μg/g) | CSF (μg/ml) | Choroid (μg/ml) | Vitreous humor (μg/ml) | Aqueous humor (μg/ml) | |
| 0.5 | 2.26 ± 0.10 | 2.05 ± 0.69 | 1.87 ± 0.09 | 1.40 ± 0.08 | 0.08 ± 0.01 | ND | 0.012 ± 0.014 | ND | ND |
| 1.0 | 5.59 ± 1.31 | 4.11 ± 0.15 | 4.30 ± 0.11 | 3.34 ± 0.14 | 0.10 ± 0.00 | ND | 0.061 ± 0.039 | 0.015 ± 0.025 | ND |
| 2.0 | 11.76 ± 1.40 | 8.82 ± 0.72 | 9.05 ± 0.25 | 6.12 ± 0.17 | 0.18 ± 0.02 | ND | 0.162 ± 0.096 | 0.034 ± 0.032 | ND |
a
All values represent the means ± SEMs for three rabbits. Tissues and body fluids were obtained 30 min after the last of eight once-daily doses of FK463. ND, not detectable.