Table 1.

Anchor based calculations of the MCID.

Visit	Mean PANSS-FSNS change from baseline (n) at the 1st instance of minimal improvement [1]	Mean PANSS-FSNS change from baseline (n) at the last recorded unchanged status [2]	MCID1 [1]	MCID2 [1]-[2]	SD of [1] and [2]	LSMD (95% CI)	P-value
Overall	−3.8 (365)	−2.3	−3.8 (18.5%)	−1.5 (7.3%)	2.5	1.7 (1.1, 2.3)	<0.0001

PANSS-FSNS, Positive and Negative Syndrome Scale-Factor Score for Negative Symptoms; n, number of events; CGI-I, Clinical Global Impression—Improvement; MCID₁ and MCID₂, Minimum clinically important differences according to the definitions in the text; SD, Standard deviation; LSMD, Least-square mean difference between [1] and [2], as estimated by MMRM, with corresponding 95% confidence limits. Please also note that for the computation of % changes from baseline the value of 7 was subtracted from the observed baseline severity (i.e., 27.6) since the minimum value of the PANSS-FSNS factor is 7 (i.e., the symptoms on all seven constituting items of the factor are rated as “Absent”).