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. 2022 Apr 25;13:838435. doi: 10.3389/fphys.2022.838435

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Copyright © 2022 Lu, Kreir, Karel, Tekle, Geyskens, Teisman and Gallacher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of Cardiac Hazard Risk of Nineteen Reference Drugs in Two iCell-Cardiomyocytes² Lots (12012 and 105091) and one iCell Cardiomyocyte Lot (103674). Reference drugs were scored for cardiac hazard using the described scoring matrix. “no TdP risk,” “TdP risk,” and “other mechanism” groups represent drug categories based on FDA labels for marketed drugs.