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. 2022 Apr 25;13:872624. doi: 10.3389/fphys.2022.872624

FIGURE 6.

FIGURE 6

Glucose uptake in WT, RYR1-p.R163C, and db/db single fibers. Effects of dantrolene. (A) Single muscle fiber recordings of 2-NBDG fluorescent signals from WT, RYR1-p.R163C, and db/db muscle. (B) Typical records of NBDG fluorescent signals show the effect of dantrolene on insulin-dependent glucose uptake in single muscle fibers WT, RYR1-p.R163C, and db/db. (C) Shows the summary of abnormal insulin-dependent glucose uptake in RYR1-p.R163C and db/db single muscle fibers and the effects of dantrolene. The florescent rate values were normalized to untreated WT and expressed as mean ± S. D; experiments were carried out in n mice = 5 per genotype; n fibers = 9–14/genotype group. Statistical analysis was performed as described above. *** = p < 0.001. Calibration bar = 5 min.