Table 2.

TA treatment methods and details for included studies

Author	Year	n treated	Age range treated*	Treatment method	Treatment time	Treatment provider	Treatment setting	Follow-up visits
Banerjee et al9	2020	136	36.7±7.3	WISAP Medical Technology GmbH, 100°C, no anaesthetic, multiple overlapping applications as needed	40 s	Auxiliary nurse midwives†	Community clinics	12 months
Campbell et al23	2016	381	–	WISAP, 100°C–120°C, no local anaesthetic, multiple overlapping applications as needed	30 s	Unspecified health worker	Facility	3 months, 6 months and 12 months
Chigbu et al18	2020	511	47.1±12.6	Device not specified, 100°C, multiple overlapping applications as needed	45 s	Not reported	Facility	6 months
Duan et al28	2021	74	31.5±5.2	Liger device, 100°C, no anaesthetic, multiple overlapping applications as needed	45 s	Gynaecologist	Facility	4, 8 months
Eakin et al24	2018	5	–	Device not specified, 100°C, no anaesthetic, multiple overlapping applications as needed	60 s	Physician	Facility	N/A
Fokom Domgue et al25	2020	161	–	WISAP Medical Technology GmbH, 100°C, multiple overlapping applications as needed	45 s	Nurse	Primary health clinic	N/A
Joshi et al10	2013	124	–	Device not specified, 105°C, no local anaesthetic, multiple overlapping applications as needed	45 s	Unspecified health worker	Community clinics	6 months
Joshi et al26	2015	27	–	WISAP Medical Technology GmbH, 105°C, no local anaesthetic, multiple overlapping applications as needed	45 s	Physician or Nurse†	Community clinics	N/A
Mungo et al19	2020	293	40.4±8.7	Liger device, 100°C, no local anaesthethic, number of applications not specified	20 s	Clinical officer—equivalent to a physician assistant in the USA†	Community clinics	4–6 weeks
Naud et al22	2016	52	31 (27–40)	WISAP Medical Technology GmbH, 100°C, no local anaesthetic, multiple overlapping applications as needed	20 s	Not reported	Facility	12 months
Pinder et al11	2020	250	–	Liger device, 100°C, no anaesthetic, multiple overlapping applications as needed	40 s	Nurse	Primary health clinic	2 weeks and 6 months
Sandoval et al20	2019	319	–	Liger device, 100°C, analgesia (NSAIDs) offered post-treatment, multiple overlapping applications as needed	45 s	Physicians†	Facility	1 month
Viviano et al21	2017	110	–	WISAP Medical Technology GmbH, 100°C, no anaesthetic, multiple applications as needed	60 s	Gynaecologist†	Facility	1 month
Zhao et al12	2021	170	41.0 (35–47)	WISAP Medical Technology GmbH or Liger device, 100°C–110°C, no anaesthetic, multiple applications as needed	45 s	Physician	Primary health clinic	1 month, 6 months, 12 months and 18 months
Zhao et al27	2020	96	–	WISAP Medical Technology GmbH or Liger device, 100°C, no anaesthetic, multiple applications as needed	45 s	Unspecified health worker	Primary health clinic	4 weeks

*Average ±SD or median (IQR).

†Based on personal communication with authors (Dr Partha Basu, 2021; Dr Smita Joshi, 2021; Dr Chemtai Mungo, 2021; Dr Silvia de Sanjose, 2021; and Dr Manuela Viviano, 2021).

NSAIDs, non-steroidal anti-inflamatory drugs; TA, thermal ablation.