Table 1.

Treatment and examination schedule

Visit	Preobservation	Treatment													Postobservation		Drop-out
	Week	0	2	4	6	8	10	12	14	16	18	20	22	24	36	48
	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16
Allowable range (days)	0–31	0	±4	±4	±4	±4	±4	±4	±4	±4	±4	±4	±4	±4	±14	±14	+7
Informed consent	●
Registration/randomisation		●
Patient information	●
TdES		●	●	●	●	●	●	●	●	●	●	●	●
Subjective symptoms review	●	●	●	●	●	●	●	●	●	●		●	●	●	●	●	●
Blood pressure measurement		〇	〇	〇	〇	〇	〇	〇	〇	〇	〇	〇	〇	〇	〇	〇	〇
Blood test	●																〇
logMAR VA	●	●	●	●	●	●	●	●	●	●	●	●	●	●	●	●	●
ETDRS VA	●	●						●						●	●	●	●
HFA 10–2	●							●						●		●	●
HFA esterman	●							●						●		●	●
OCT	●							●						●	●	●	●
NEI VFQ-25	●							●						●		●	●
Slit lamp microscopy	●				●			●						●	●	●	●
IOP/fds	●				●			●						●	●	●	●
Pregnancy test	●																〇
Adverse event observation

Black circles are items that must be performed. White circles are items to be performed only when the investigator deems it necessary.

ETDRS, Early Treatment Diabetic Retinopathy Study; fds, fundus examination; HFA, Humphrey field analyser; IOP, intraocular pressure; LogMAR, logarithm of the minimum angle of resolution; NEI VFQ-25, 25-item National Eye Institute Visual Function Questionnaire; OCT, optical coherence tomography; TdES, transdermal electrical stimulation; VA, visual acuity.