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. 2022 May 9;52(4):427–441. doi: 10.1007/s40005-022-00573-z

Fig. 5.

Fig. 5

Strategies for organelle acidic pH-responsive nanoparticles. a Proton sponge effects: The acid-triggered drug release from the pH-sensitive mixed micelles. c Osmotic lysis: Schematic of structure and composition of lipid-coated PBAE particles and mRNA cargo association. c Membrane disruption: Schematic diagram of endosomal pH-responsive triblock copolymer nanovesicles which contain poly-ImHeMA. Panels a, b, and c are reproduced with permission from Wu et al. (2013), Su et al. (2011), and (Gallon et al. 2015), respectively