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. Author manuscript; available in PMC: 2022 May 9.
Published in final edited form as: J Cancer Metastasis Treat. 2022 Mar 31;8:12. doi: 10.20517/2394-4722.2022.03

Figure 6.

Figure 6.

MUC1-C dictates JUN and BAF-mediated chromatin remodeling at a proximal enhancer-like signature (pELS) in the NOTCH1 gene. MUC1-C interacts directly with JUN to form a complex that occupies a pELS in the NOTCH1 gene. In turn, MUC1-C-JUN complexes recruit BAF, as evidenced by MUC1-C-dependent occupancy of both JUN and ARID1A. MUC1-C is necessary for increasing (i) chromatin accessibility, and (ii) H3K27ac and H3K4me3 marks at the pELS in association with the activation of NOTCH1 expression. Modified from Bhattacharya[57].