TABLE 2.
Susceptibility of BexA multidrug resistance pump to potential inhibitors
| Inhibitora | Norfloxacin MIC (μg/ml)
|
||
|---|---|---|---|
| AG102AX/pBR322 | AG102AX/pBRBT201 | AG102AX/pBRBT201ME | |
| None | 0.03 | 0.25 | 0.25 |
| Reserpine (20 μg/ml) | 0.015 | 0.06 | 0.06 |
| Reserpine (100 μg/ml) | 0.015 | 0.06 | 0.06 |
| Verapamil (20 μg/ml) | 0.015 | 0.06 | 0.06 |
| Verapamil (100 μg/ml) | 0.015 | 0.015 | 0.015 |
| MC 207,110 (10 μg/ml) | 0.015 | 0.125 | 0.125 |
| MC 207,110 (15 μg/ml) | 0.015 | 0.015 | 0.06 |
a
These inhibitors inhibited the growth of the E. coli strains at high concentrations; and the MICs of reserpine, verapamil, and MC 207, 110 for AG102AX/pBR322 were >512, 512, and 64 μg/ml, respectively.