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. 2022 Apr 25;13:878201. doi: 10.3389/fimmu.2022.878201

Figure 1.

Figure 1

Schematic representation of potential mechanisms of SARS-CoV-2 infection in neurodegeneration. SARS-CoV-2 infection causes severe upregulation of proinflammatory cytokines and chemokines (so called “cytokine storm”) leading to increased permeability of BBB and blood-CSF barrier, and initiating CNS invasion This event also involves overactivation of glial cells that can promote detrimental effects, indirectly and/or directly, by inducing synapse loss, oxidative injury and further contributing to neuronal degeneration.

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