Table 1.
Baseline Characteristics of Chronic Renal Insufficiency Cohort (CRIC) Study Participants by Self-reported Race
| Variables | Overall (n=3873) | Self-reported Race | |
|---|---|---|---|
| Black (n=1631) | Non-Black (n=2242) | ||
| Age, mean (SD), years | 57.8 (10.9) | 57.8 (10.5) | 57.8 (11.2) |
| Male, No. (%) | 2122 (54.8) | 796 (48.8) | 1326 (59.1) |
| Body mass index, mean (SD), kg/m2 | 32.1 (7.8) | 33.5 (8.3) | 31.1 (7.3) |
| Current smoking, No. (%) | 510 (13.2) | 318 (19.5) | 192 (8.6) |
| Hemoglobin A1C, mean (SD), % | 6.6 (1.6) | 6.9 (1.7) | 6.5 (1.4) |
| Diabetes mellitus, No. (%) | 1868 (48.2) | 842 (51.6) | 1026 (45.8) |
| Use of glucose-lowering medications, No. (%) | 1063 (27.6) | 467 (28.8) | 596 (26.8) |
| Systolic blood pressure, mean (SD), mm Hg | 128.3 (22.0) | 132.6 (22.9) | 125.1 (20.8) |
| Diastolic blood pressure, mean (SD), mm Hg | 71.4 (12.7) | 73.6 (13.7) | 69.9 (11.7) |
| Use of blood pressure-lowering medications, No. (%) | 3536 (91.3) | 1547 (94.8) | 1989 (88.7) |
| Urinary PCR, median [IQR], mg/g | 154.2 [58.1, 785.2] | 199.3 [61.8, 870.3] | 132.7 [55.6, 695.3] |
| Estimated glomerular filtration rate, mean (SD), mL/min/1.73 m2 * | |||
| Creatinine-based with age, sex, and race | 44.2 (15.0) | 43.6 (15.0) | 44.7 (15.0) |
| Creatinine-based with age and sex | 44.4 (15.3) | 40.0 (13.5) | 47.5 (15.7) |
| Cystatin C-based with age and sex | 52.8 (23.8) | 50.9 (23.1) | 54.2 (24.2) |
| Creatinine- and cystatin C-based with age, sex, and race | 47.3 (18.6) | 46.0 (18.3) | 48.2 (18.8) |
| Creatinine- and cystatin C-based with age and sex | 49.2 (19.6) | 46.0 (18.3) | 51.6 (20.2) |
| Predicted 2-year risk of ESKD, mean (SD), % † | |||
| Creatinine-based with age, sex, and race | 5.0 (10.9) | 5.3 (11.0) | 4.8 (10.8) |
| Creatinine-based with age and sex | 5.1 (11.0) | 6.5 (12.5) | 4.1 (9.7) |
| Cystatin C-based with age and sex | 4.8 (11.1) | 5.2 (11.1) | 4.5 (11.0) |
| Creatinine- and cystatin C-based with age, sex, and race | 5.2 (11.3) | 5.6 (11.4) | 4.9 (11.3) |
| Creatinine- and cystatin C-based with age and sex | 4.9 (11.0) | 5.7 (11.7) | 4.3 (10.4) |
| 2-year Kaplan-Meier observed risk of ESKD, % (95% CI) | 5.9 (5.2, 6.7) | 6.5 (5.3, 7.7) | 5.5 (4.6, 6.5) |
ACR = albumin-to-creatinine ratio; CKD-EPI = Chronic Kidney Disease Epidemiology Collaboration; ESKD = end-stage kidney disease; IQR = interquartile range; PCR = protein-to-creatinine ratio; SD = standard deviation
*
Calculated based on the CKD-EPI equations
†
Calculated using the 4-variable Kidney Failure Risk Equation (including age, sex, eGFR, and urinary ACR) with glomerular filtration rate estimated using the CKD-EPI equations and urinary ACR converted from urinary PCR