Table 3.

Reclassification of ESKD Events and Non-events by Kidney Failure Risk Equation Scores Using Various Equations

	Black Participants			Non-Black Participants
Model Comparisons *	Events Reclassified, % (95% CI)	Non-events Reclassified, % (95% CI)	Net Reclassification Index (95% CI)	Events Reclassified, % (95% CI)	Non-events Reclassified, % (95% CI)	Net Reclassification Index (95% CI)
Comparing with creatinine-based equation with age, sex, and race
Creatinine with age and sex	7.0 (4.6, 9.5)	−3.8 (−4.3, −3.2)	3.2 (0.5, 5.9)	−5.6 (−7.8, −3.6)	2.8 (2.4, 3.2)	−2.8 (−5.1, −0.8)
Cystatin C with age and sex	−6.3 (−11.3, −1.6)	0.2 (−0.7, 0.9)	−6.1 (−11.1, −1.4)	−7.0 (−11.0, −2.9)	0.4 (−0.2, 0.9)	−6.6 (−10.8, −2.5)
Creatinine and cystatin C with age and sex	3.2 (−0.4, 6.4)	−1.6 (−2.3, −1.0)	1.6 (−2.1, 4.7)	−5.7 (−9.0, −2.5)	1.4 (0.9, 1.8)	−4.3 (−7.7, −1.2)
Comparing with creatinine-based equation with age and sex
Cystatin C with age and sex	−12.0 (−16.6, −7.5)	3.4 (2.5, 4.3)	−8.6 (−13.3, −4.0)	−2.7 (−7.0, 1.5)	−2.0 (−2.6, −1.5)	−4.7 (−8.9, −0.3)
Creatinine and cystatin C with age and sex	−3.6 (−6.8, −0.5)	2.0 (1.3, 2.7)	−1.5 (−4.8, 1.7)	−0.5 (−4.1, 3.0)	−1.3 (−1.8, −0.9)	−1.8 (−5.5, 1.7)

CI = confidence interval; eGFR = estimated glomerular filtration rate; ESKD = end-stage kidney disease

^*Models are compared for reclassification of ESKD events to a higher predicted risk category and non-events to a lower predicted risk category, using cut-off points of 10% and 20%. Values >0 indicate correct reclassification while values <0 indicate incorrect reclassification.