Fig. 2.

Encapsulation efficiency (EE) and drug loading wt% (DL) of a) ET SNP, b) CPP SNP, c) ET in DNPs, and d) CPP in DNPs. a) ET encapsulation efficiency decreased, but total drug loading increased as the feed ratio was increased. b) While CPP drug loading increased with feed ratio, encapsulation efficiency remained consistent throughout. In c) and d) the ET feed ratio was kept constant at 25% in DNPs and the CPP feed ratio was varied. A CPP feed ratio of 7.5% produced the loaded 1:1.8 ET:CPP molar ratios used in all further studies in vivo.