Results of pathway analysis using MetaboAnalyst^a.

No.	Pathway name	Hits	Total	P-value	−log(p)	FDR	Impact
1	Aminoacyl-tRNA biosynthesis	7	67	4.0088 × 10−5	10.124	0.0032471	0.0
2	Valine, leucine and isoleucine biosynthesis	3	11	5.1084 × 10−4	7.5795	0.020689	0.99999
3	Butanoate metabolism	3	20	0.0032192	5.7386	0.08692	0.0
4	Valine, leucine and isoleucine degradation	3	38	0.019827	3.9207	0.40151	0.0
5	Propanoate metabolism	2	20	0.037657	3.2792	0.47441	0.0
6	Pyruvate metabolism	2	22	0.044926	3.1027	0.47441	0.05583
7	Alanine, aspartate and glutamate metabolism	2	24	0.052676	2.9436	0.47441	0.0
8	Glycolysis/gluconeogenesis	2	26	0.060871	2.799	0.47441	0.02862
9	Galactose metabolism	2	26	0.060871	2.799	0.47441	0.03644
10	Phenylalanine, tyrosine and tryptophan biosynthesis	1	4	0.06137	2.7908	0.47441	0.5
11	Synthesis and degradation of ketone bodies	1	5	0.076141	2.5752	0.47441	0.0
12	d-Glutamine and d-glutamate metabolism	1	5	0.076141	2.5752	0.47441	0.0
13	Biotin metabolism	1	5	0.076141	2.5752	0.47441	0.0
14	Taurine and hypotaurine metabolism	1	8	0.11913	2.1275	0.68928	0.42857
15	Phenylalanine metabolism	1	9	0.13304	2.1275	0.71839	0.40741
16	Selenoamino acid metabolism	1	15	0.21215	1.5505	1.0	0.0
17	Pantothenate and CoA biosynthesis	1	15	0.21215	1.5505	1.0	0.0
18	Glycerolipid metabolism	1	18	0.24907	1.39	1.0	0.28098
19	Citrate cycle (TCA cycle)	1	20	0.27277	1.2991	1.0	0.02566
20	Starch and sucrose metabolism	1	23	0.30697	1.181	1.0	0.03778
21	Tryptophan metabolism	1	41	0.4821	0.7296	1.0	0.15684
22	Arginine and proline metabolism	1	44	0.50683	0.67958	1.0	0.03042
23	Primary bile acid biosynthesis	1	46	0.52269	0.64877	1.0	0.03042

^aThe “Total” is the number of compounds in the pathway; the “Hits” represents the actual matched number from the user uploaded data.