Table 2.
Cytogenetic abnormalities in 306 patients with t-MDS/t-AML (t-MDS 224, t-AML 82). Balanced chromosomal translocations are very rare in t-MDS where abnormalities of chromosomes 5 or/and 7 are prevalent. From Smith et Al.20 Blood. 2003
| Presentation | N∘ patients | Abnormality 5 (%) | Abnormality 7 (%) | Abnormalities 5 and 7 (%) | Balanced rearrangement (%) |
|---|---|---|---|---|---|
| I-MDS-unknown | 54 | 10 (19) | 20 (37) | 9 (17) | 2 (4) |
| I-MDS only | 72 | 19 (26) | 16 (22) | 17 (24) | 0 |
| I-MDS-+-−M-AML | 98 | 19 (19) | 32 (33) | 28 (29) | 6 (6) |
| I-AML only | 82 | 14 (17) | 16 (20) | 12 (15) | 23 (28) |
| Totals | 306 | 62 (20) | 84 (27) | 66 (22) | 31 (10) |
| Karyiotype | N∘ (%) |
|---|---|
| Normal karyotype | 24(8) |
| Clonal abnormalities | 282 (92) |
| Clonal abnormalities of chromosome 5, 7, or both | |
| (± other abnormalities) | 214 (70) |
| Abnormal chromosome 5* | 63 (21) |
| Abnormal chromosome 7* | 85 (28) |
| Abnormal chromosomes 5 and 7 | 66 (22) |
| Recurring balanced rearrangements | 31 (10) |
| t(11q23) | 10 (3.3) |
| t(21q22)* | 8 (2.6) |
| t(15:17) | 6 (2.0) |
| inv(16)* | 6(2.0) |
| t(8:16) | 1 (0.3) |
| Other clonal abnormalities | 39 (13)Ϯ |