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. 2022 May 9;9(3):032212. doi: 10.1117/1.NPh.9.3.032212

Fig. 5.

Fig. 5

FRET-signal change and increase in lactate level caused by lactate injection. Data points of individual animals are connected by lines. Individual change of the FRET signal in (a) n=5 Twitch-2B-expressing and (b) n=8 Laconic-expressing animals upon lactate injection, before (left) and after (right) application of the correction algorithm. Only values with SNR3 (black) were considered as FRET-signal change. Values with SNR<3 (gray) were classified as no signal change. (c) Lactate level in blood plasma before (left) and after injection (right) of lactate (1  mmol/kg) in n=3 animals. (d) Relative increase in cortical lactate level caused by lactate injection (2.5  mmol/kg) as determined by MRS in n=5 animals.