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. 2022 Apr 25;13:810671. doi: 10.3389/fimmu.2022.810671

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Copyright © 2022 Jiang, Tang, Zhang, He, Yu, Chen, Xia, Lin and Ou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knocking down CCN1 expression attenuated liver injury and inflammation in ConA induced hepatitis mice. (A) Representative H&E staining images of liver tissues from ConA induced hepatitis mice. Original magnification ×200 (left, upper, scale bar: 50 µm), ×1000 (right, scale bar: 10 µm). (B) Serum levels of both ALT and AST in CCN1 ^fl/fl Cre⁺ (blue circle), CCN1 ^fl/fl (red circle) and control (black circle) mice. (C) mRNA expression of inflammatory cytokines IFN-γ, IL-17, IL-6 and TNF-α in PBMC from CCN1 ^fl/fl Cre⁺ and CCN1 ^fl/fl mice. (D) mRNA expression of IFN-γ, IL-17, IL-6 and TNF-α in PBMC from CCN1 ^fl/fl Cre⁺ and CCN1 ^fl/fl mice. (E) mRNA expression of IFN-γ, IL-17, IL-6 and TNF-α in liver from CCN1 ^fl/fl Cre⁺ and CCN1 ^fl/fl mice. *p<0.05, ***p<0.001.