Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 25;13:810671. doi: 10.3389/fimmu.2022.810671

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Jiang, Tang, Zhang, He, Yu, Chen, Xia, Lin and Ou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

CCN1 induced IL-6 production in LO2 cells. (A) IFN-γ, IL-17, IL-6 and TNF-α concentration in supernatant of LO2 cells stimulated by CCN1 (5 μg/ml). (B) IL-6 concentration in supernatant of LO2 cells stimulated by CCN1 (2.5, 5, 7.5, 10μg/ml). (C) CCN1 mRNA expression in CCN1-knockdown LO2 cells. (D) CCN1 protein expression in CCN1-knockdown LO2 cells. The relative expression of CCN1 protein was expressed by gray value. (E) IL-6 mRNA expression in LO2 cells treated with SiCCN1 (small interfering RNA against CCN1, black bar) or SiNC (small RNA of negative control, open bar). (F) IL-6 level in culture supernatant of LO2 cells treated with SiCCN1 or SiNC. *p<0.05, **p<0.01. All experiments were independently repeated at least three times in triplicate.